the Screamin Eagle tuners do not need to have anything done to the throttle body or the TPS as that is one of the variables that you cannot affect on the tuning.
with items like the PCIII you do whats known as a sweep test with the bike on but not running to set the WOT and zero marks same with the Vance and Hines Fuelpak.
As you have posted this in the Buell section i am assuming you have an older Buell and looking to put the older Buell tuner on the bike, this is basically plug and play and no TPS adjustment needed.
Do you have any more info - bike, year, Tuner?