Long story but I'll try to give as many details as possible. Bike is an '08 FLHX with Stage I and GEN4 TFI. Embarked yesterday morning on the 2 hour ride up to Athens to meet my daughter for brunch. First 30 to 40 minutes were totally uneventful - bike running perfect. At a steady 65MPH in 6th gear with the cruise control engaged, the bike suddenly hesitated for a split second but went right back to running fine. Then it started doing it more frequently and actually kicked the cruise control off. I have the GEN4 AFR gauge mounted on my left handlebar and I noticed it was running in the steady green zone but the AFR was pegged full lean - 16 plus and not moving. I could vary the throttle and get it into the yellow and red zones but the AFR remained pegged. Since I hadn't ridden in a long time and was down to about 1/3 of a tank of gas, I suspected part of the problem may have been stale fuel and/or water in the fuel. I pulled into a gas station, topped off the tank, and even added some ethanol treatment. Got back on the highway and it started getting worse. I aborted the original mission and headed for home. Got to the point that I could barely hold 55MPH even though the TFI showed I was in the red, full throttle zone and I couldn't get the RPM above 3000. Closer to home it got so bad I was riding on the shoulder with emergency flashers on barely doing 20MPH. The last couple miles to my house is normal, non interstate roads. I barely made it home, having to feather the clutch like crazy moving out from every red light. The bike just had absolutely no oomph at all. Pulled the codes when I got home and got a P1353 and a P1356 - Front and Rear Cylinder No Combustion. Much internet research points to a lot of electrical culprits with these codes - coil, plugs, plug wires. But I'm also suspicious of the TFI showing such a lean AFR the whole time. Can it get so lean that the bike's computer interprets that as "no combustion?" Once it throws those codes, does it automatically put you in "limp" mode? That's what it felt like to me after reading the description from others. Bad thing is I'm not going to be able to begin trouble shooting this problem for another week. Just thought I'd throw it out on the forum and start getting ideas and advice.