I'm not crazy about them. I have a set on my bike (they came with it) and I don't really like"bubbly" feeling. I guess they're supposed to reduce vibration through the handlebars but I don't really know if that's a real issue on bikes these days. Do they make a difference? If I switch to "regular" round grips, will I notice a difference in felt vibration? I like the simpler styles of grips but I'm willing to "tolerate" the iso-grips if they save my hands on long runs.